High dose thiotepa

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WebHigh-dose thiotepa, in conjunction with melphalan, followed by autologous hematopoietic stem cell transplantation in patients with pediatric solid tumors, … WebHigh-dose therapy (HDTx) with autologous stem cell rescue has been widely applied in very-poor-risk pediatric solid tumors. Promising data have become available with the use …

Thiotepa-based high-dose therapy for autologous stem cell ...

Web20 de nov. de 2000 · The choice of the busulfan-thiotepa combination was based on pharmacologic evidence that both drugs readily cross the blood-brain barrier. In a study of plasma and CSF profiles among children who were treated with high dose busulfan, 37 the CSF to plasma ratio was 0.95 (range, 0.5–1.4). Web15 de set. de 2000 · High-dose thiotepa, used as a single agent or combined with other cytotoxics and supported by hematopoietic stem cell transplantation (HSCT), has been … truong insurance agency

High-dose thiotepa, in conjunction with melphalan, followed by ...

Webx when high dose chemotherapy with HPCT support is appropriate for the treatment of solid tumours in adult and paediatric pati ents. 4.2 Posology and method of administration Thiotepa Riemser administration must be supervised by a physician experienced in conditioning treatment prior to haematopoietic progenitor cell transplantation. Posology WebThiotepa and Your Skin If you are receiving “High Dose” Thiotepa (>500mg/m2), you are at risk for skin problems because the excreted drug can come through the skin in sweat. Skin problems can occur anywhere. They may be worst in the groin, armpits, creases, neck area and under dressings. Web1 de abr. de 2024 · Table 1 Patient Characteristics Before ASCT (n [ 212) - "Thiotepa, Etoposide, Cyclophosphamide, Cytarabine, and Melphalan (TECAM) Conditioning Regimen for Autologous Stem Cell ... Thiotepa-based high-dose therapy for autologous stem cell transplantation in lymphoma: a retrospective study from the EBMT. L. Sellner, A. … philippines time and date today

Thiotepa-based high-dose therapy for autologous stem cell ...

Thiotepa Uses, Side Effects & Warnings - Drugs.com

WebThe usual melphalan dose is 200 mg/m 2, although a ‘risk-adapted’ approach, with dose reduction to 140 mg/m 2 used in higher-risk patients in order to reduce transplant-related toxicity. r Criteria for defining ‘high-risk’ patients are; age >60, increased creatinine level, performance status (PS) 2 or compensated cardiac failure. Web12 de set. de 2024 · Thiotepa was approved for use in the United States in 1959. Current indications include ovarian and breast cancer and Hodgkin disease. Thiotepa is also administered locally for bladder cancer, … truong giang seafood jscWebPrzepiorka D, Nath R, Ippoliti C, Mehra R, Hagemeister F, Diener K, Dimopoulos M, et al. A phase I-II study of high-dose thiotepa, busulfan and cyclophosphamide as a preparative regimen for autologous transplantation for malignant lymphoma. Leuk Lymphoma. 1995; 17:427–33. [Abstract: 7549833] truong phat electromechanical equipment

"Web1 de nov. de 2024 · Thiotepa for injection may cause severe marrow suppression, and high doses may cause marrow ablation with resulting infection or bleeding. Monitor … " - High dose thiotepa

High dose thiotepa

Web9 de set. de 2014 · Therefore, high-dose rituximab was combined with TBC for ASCT in patients with CNS NHL. METHODS. A single-arm phase 2 trial using high-dose rituximab with cytarabine for stem cell mobilization followed by high-dose rituximab combined with thiotepa, busulfan, and cyclophosphamide (R-TBC) for ASCT was conducted. Web17 de ago. de 2015 · Until today, virtually all other drugs known to cross the BBB (procarbazine, etoposide, ifosfamide, thiotepa, carmustine [BCNU], and others) have been used mostly in combination with MTX and/or Ara-C to further improve results. 26–28 As with MTX and Ara-C, most other drugs seem to be most effective at high doses, …

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WebThiotepa has been used recently at high doses in combination chemotherapy with cyclophosphamide in patients with refractory malignancies treated with autologous bone transplantation (Henner et … Web2 de nov. de 2015 · No toxicity-related death was associated with high-dose (HD) thiotepa. The median hospital stay was 24 days (range 19–49). HD busulfan–melphalan (n=24)

Web11 de abr. de 2003 · High-dose thiotepa, busulfan, cyclophosphamide and ASCT without whole-brain radiotherapy for poor prognosis primary CNS lymphoma. T Cheng 1,2, P … WebThe incidence of neurotoxicity related to the combination of WBRT and high dose methotrexate is significantly higher in patients aged older than 60 years; withholding WBRT in the primary setting in these patients may be considered. Consider reducing or omitting cytarabine and thiotepa doses in older patients and/or those with co-morbidities.

Web11 de abr. de 2003 · High-dose thiotepa, busulfan, cyclophosphamide and ASCT without whole-brain radiotherapy for poor prognosis primary CNS lymphoma. T Cheng 1,2, P Forsyth 2,3, A Chaudhry 1,2, D Morris 1,2, Web19 de abr. de 2004 · Children with high-risk and recurrent brain tumors currently have a poor prognosis. 1-5 To increase brain distribution of antitumor drugs that do not cross the blood-brain barrier at conventional dosages and to achieve higher concentrations within the tumor, high-dose chemotherapy (HDCT) followed by autologous hemopoietic stem cell …

Web31 de out. de 2002 · High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma J Clin Oncol 1998 16: 222 228 Article CAS Google Scholar

Web30 de jun. de 2024 · The pharmacokinetics of high dose thiotepa in children between 2 and 12 years of age do not appear to vary from those reported in children receiving 75 mg/m 2 or adults receiving similar doses. Renal impairment. The effects of renal impairment on thiotepa elimination have not been assessed. truong international saigon pearlWeb15 de set. de 2024 · Disclosed are methods of treating cancer with a tri-agent therapy. The methods include a cancer treatment regimen with two or three different antineoplastic medications, including tamoxifen, gefitinib, and vinorelbine (TGV). The cancer treatment regimen can include sequential and/or concurrent administration of tamoxifen, gefitinib, … philippines ticket price from indiaWebHigh-dose chemotherapy conditioning regimens followed by autologous stem cell transplantation generally provide good results in non-Hodgkin lymphoma. We … philippines time difference sydneyWeb3 de abr. de 2024 · It is interesting to note that 9 patients were treated as part of a phase 2 trial of high-dose thiotepa, busulfan, and cyclophosphamide and high-dose rituximab … philippines time difference to ukWeb15 de ago. de 2024 · High-dose chemotherapy with thiotepa, busulfan, and cyclophosphamide and autologous stem cell transplantation for patients with … philippines time difference with indiaWeb13 de fev. de 2024 · Background: Serious neurological adverse events (NAE) have occurred during treatment with high-dose thiotepa regimens of children with high-risk solid … philippines time difference from usWeb21 de set. de 2016 · Alkylating agents have been shown to be active against both CNS and systemic GCTs 27 and given that their dose-limiting toxicity is primarily hematologic, these are attractive agents for high-dose therapy followed by ASCR. Thiotepa, 28 specifically, has been shown to cross the blood-brain barrier extremely efficiently and has a mild … philippines time clock today with seconds