Fat mass mendelian randomization
WebJun 30, 2024 · Fat mass and fat-free mass are found to be associated with different health outcomes in observational studies, but the underlying causality remains unclear. We aimed to investigate the causal relationships between body composition and cardiometabolic traits using a two-sample Mendelian randomization (MR) approach. WebChildhood: A Mendelian Randomization Study Raquel Granell1*, A. John Henderson1, David M. Evans2,3, George Davey Smith2, Andrew R. Ness4,5, ... of fat mass and lean mass included in the analyses were calculated as the residuals from a linear regression of each on gender, height,
Fat mass mendelian randomization
Did you know?
WebApr 11, 2024 · Abstract. Background: The association between fat mass and mortality has been equivocally shown to be linear, J-shaped, and U-shaped. We aimed to clarify this relationship based on Mendelian randomization (MR) analysis and lifestyle modification. WebJul 1, 2014 · In Mendelian randomization, causality is inferred from associations between genetic variants that mimic the effect of a modifiable risk factor and the outcome of interest. Because gene variants are …
WebBackground: The association between fat mass and mortality has been equivocally shown to be linear, J-shaped, and U-shaped. We aimed to clarify this relationship based on … WebJun 13, 2024 · The causal role of adiposity for several cardiovascular diseases (CVDs) is unclear. Our primary aim was to apply the Mendelian randomization design to investigate the associations of body mass index (BMI) with 13 CVDs and arterial hypertension. We also assessed the roles of fat mass and fat-free mass on the same outcomes.
WebJan 21, 2024 · Purpose The causal effects of body fat mass and body fat-free mass on coronavirus disease 2024 (COVID-19) severity remain unclear. Here, we used Mendelian randomization (MR) to evaluate the causal relationships between body fat-related traits and COVID-19 severity. Material and Methods We identified single nucleotide … WebAlcoholic liver disease was consistently associated with WC even after adjusting for alcohol consumption in a multivariable Mendelian randomization analysis. The odds ratio per 1-SD increase in genetically predicted WC (12.52 cm) for such associations ranged from 1.41 (95% CI: 1.17–1.70; p = 0.0015) for gastric cancer to 1.74 (95% CI: 1.21 ...
WebMar 15, 2024 · Introduction. Breast cancer is the most frequent malignancy in women worldwide, mainly affecting women over the age of 50 [].Epidemiological studies have identified several risk factors for breast cancer such as aging, family history and lifestyles like alcohol consumption and dietary fat intake [].However, the identified risk factors …
WebMay 3, 2024 · We performed a two-sample Mendelian randomization analysis to investigate the causal relationship between different central obesity measures and BMD. This study suggests there are variations in the ability of … pmd garment dye drop shoulder t-shirtWebIn this study, Granell and colleagues used Mendelian randomization to investigate causal effects of BMI, fat mass, and lean mass on current asthma at age 7½ years in the Avon … pmd gates to infinity romWebMendelian randomization analyses were conducted to validate the causal associations of those various exposures with lung cancer using summary statistics from 10 genome-wide association studies... pmd hatchWebMethods: We used summary statistics from genome-wide association studies for body mass index (BMI), waist-to-hip ratio (WHR), and multiple cerebrovascular disease phenotypes. … pmd hairWebMendelian randomization (MR) analysis uses functional polymorphisms (single nucleotide polymorphisms (SNPs)) associated with specific changes in exposures (in this case, … pmd gymwearWebMendelian Randomization Analysis Dissects the Relationship between NAFLD, T2D, and Obesity and Provides Implications to Precision Medicine. Zhipeng Liu, ... the … pmd headsWebNon-alcoholic fatty liver disease (NAFLD) is a complex disease associated with premature mortality. Its diagnosis is challenging, and the identification of biomarkers causally influenced by NAFLD may be clinically useful. We aimed at identifying blood metabolites causally impacted by NAFLD using two-sample Mendelian randomization (MR) with … pmd healthcare