Dynein intermediate chain 2
WebFeb 5, 2013 · 605483 - DYNEIN, AXONEMAL, INTERMEDIATE CHAIN 2; DNAI2 - DNAI2 In 3 patients with primary ciliary dyskinesia-9 (CILD9; 612444), Loges et al. (2008) … WebJul 1, 2024 · The Wdr34 gene encodes an intermediate chain of cytoplasmic dynein 2, the motor for retrograde intraflagellar transport (IFT) in primary cilia. Although mutations in human WDR34 have recently been reported, the association of WDR34 function with Hedgehog (Hh) signaling has not been established, and actual cilia defects in the …
Dynein intermediate chain 2
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WebThese results suggest that cytoplasmic dynein 1 binds to BRCA2 through the latter's centrosomal localization signal and BRCA2 mediates the cohesion between centrosomes during the S phase, potentially serving as a cell-cycle checkpoint. although dynein lacking light intermediate chains (LICs) drives microtubule gliding at normal rates, the LICs ... WebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated …
WebThe light intermediate chains associate in the dynein complex only as homoligomers. b Each light chain family has at least 2 members. Table II. Composition of … WebDec 23, 2016 · Dynein is a large, non-covalent cytoplasmic complex of protein subunits including heavy chains, intermediate chains, light …
WebCentral to the function of this motor protein complex is dynein intermediate chain (IC), which binds the three dimeric dynein light chains at … WebJan 7, 2024 · The light intermediate chain 2 subpopulation of dynein regulates mitotic spindle orientation. Sci Rep. 2016; 6(1):22. pmid:28003657 . View Article PubMed/NCBI Google Scholar 52. Mahale SP, Sharma A, Mylavarapu SV. Dynein light intermediate chain 2 facilitates the metaphase to anaphase transition by inactivating the spindle …
WebThe intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins.
WebDynein intermediate chain 2, ciliary. Organism names. Organism. Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) Taxonomic identifier. 1043166 NCBI. Taxonomic … slow cook silverside beef recipesWebCoordinated movement of the dynein arms causes the entire axoneme to bend back and forth. IDAs and ODAs have different combinations of protein components (subunits) that are classified by weight as heavy, intermediate, or light chains. The DNAI1 gene provides instructions for making intermediate chain 1, which is found in ODAs. Other subunits ... slow cook shrimp recipeWebFeb 14, 2024 · Mutations in the gene encoding the heavy chain of the cytoplasmic dynein-1 (dynein) motor have repeatedly been implicated in neurological diseases (1–13).Dynein is a 1.4-MDa complex that is responsible for the vast majority of cargo transport toward the minus ends of microtubules (14, 15).The complex consists of two copies each of the 530 … slow cook shredded chicken recipeWebMar 30, 2024 · The other dynein-2 subunits – namely, the intermediate and light chains – form a stoichiometrically unusual subcomplex at the core of the tail of dynein-2, which makes its structure highly asymmetric (Toropova et al., 2024). While dynein-1 is composed of homodimeric subunits, including its intermediate chain, dynein-2 differs notably in ... software bandungWeb1 day ago · All light and intermediate chains are present, and only the ODA-DC complex is missing ... MTBS2 where the dynein in post-2 conformation fits well with our map. (J) … software bandwidth limiterWebNov 1, 2024 · Dynein axonemal intermediate chain 2 (Dnaic2) is a homologue of human DNAI2, which is associated with PCD.21 Dnaic2 is highly expressed in oocytes and sperms. Dnaic2‐overexpressed mice show lung damage, male sterility, and female subfertility or … slow cook shredded beefWebFeb 10, 2024 · Here, we identified cytoplasmic dynein 1 intermediate-chain 2 genes in M. oryzae and functionally characterized it using genetic manipulations, and biochemical approaches. We observed that targeted the deletion of MoDYNC1I2 caused significant vegetative growth defects, abolished conidiation, and rendered the Δ Modync1I2 strains … slow cook shredded pork