Ctcf and ctcfl in cancer
WebMay 11, 2024 · Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is … WebBACKGROUND: BORIS/CTCFL, a paralog of CTCF and member of the cancer-testicular antigen family, is abnormally activated in multiple cancers. OBJECTIVE: We investigated …
Ctcf and ctcfl in cancer
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WebThe LOF of CTCF or cohesin in cancer may cause activation of oncogenes through altering chromatin loops (Fig. 4). CTCF is frequently mutated in endometrial carcinoma, head … WebNov 15, 2013 · Estrogens play a key role in breast cancer, with 60–70% of the cases expressing estrogen receptors (ERs), which are encoded by the ESR1 gene. CTCFL, a paralogue of the chromatin organizer CTCF, is a potential biomarker of breast cancer, but its expression in this disease is currently controversial.
WebApr 1, 2024 · In this regard, BORIS (CTCFL), a CTCF paralog, is a promising cancer biomarker that is overexpressed and controls transcription in several cancer types, mainly in OC. Web2 days ago · Cancer remains the main cause of human death worldwide, and most cancers still lack effective prevention and treatment means [].In recent years, immune checkpoint (ICP) blockade and targeted drug therapy have greatly improved the therapeutic effect of cancer patients, but there are still problems such as limited patient benefit and difficulty …
WebNov 2, 2024 · However, in cancer, CTCF is substituted by CTCFL/BORIS, depicted as a blue circle, shutting down the transcription of these tumor suppressor genes through activation of anti-sense transcripts. The … WebNational Center for Biotechnology Information
WebNov 2, 2024 · However, in cancer, CTCF is substituted by CTCFL/BORIS, depicted as a blue circle, shutting down the transcription of these tumor suppressor genes through activation of anti-sense transcripts. The …
WebMay 4, 2024 · In recent years, the most extensively studied disease related to CTCF protein is cancer. Debaugny and Skok reviewed the oncogenic roles of CTCF and CTCFL (CTCF-like or BORIS; the paralog of CTCF, see below section for BORIS). Human IDH gene mutant gliomas exhibit DNA hypermethylation, which ... how long are mepilex dressings good forWebIn ovarian cancer CTCFL expression indeed correlates with advanced stage and decreased survival . In other tumor types CTCFL expression has also been detected, although … how long are methamphetamines in the urineWebApr 1, 2024 · In this regard, BORIS (CTCFL), a CTCF paralog, is a promising cancer biomarker that is overexpressed and controls transcription in several cancer types, … how long are milesWebMar 29, 2024 · CTCF and CTCFL in cancer. Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress. Defining the relative and combined contribution … how long are meters in feetWebCancer; Cell Biology; Stem Cells & Development; Metabolic & Cardiovascular Disease; ... 我们为您找到 ctcf 的 1 个相关产品结果。 ... Synonyms: CTCFL;BORIS;CT27;CTCF-T;HMGB1L1;dJ579F20.2. Type: Rabbit Polyclonal Antibody (1) 加入对比 （最多5 ... how long are messages kept in icloudWebIn ovarian cancer CTCFL expression indeed correlates with advanced stage and decreased survival . In other tumor types CTCFL expression has also been detected, although expression data have been contradictory . According to the TCGA data, CTCFL is mainly expressed in ovarian cancer (Supplementary Figure 2). how long are minecraft dayWebOct 1, 2024 · Using the Kaplan Meier plotter the prognostic significance of mRNA levels of CTCFL in gastric, breast, and ovarian cancer were interrogated, similarly to the respective levels of CTCF. In gastric cancer high CTCFL mRNA expression levels are associated with worse OS compared with gastric cancers having low CTCFL mRNA expression (HR = … how long are microsoft accounts locked for